Additive Dose Response Models: Explicit Formulation and the Loewe Additivity Consistency Condition

High-throughput techniques allow for massive screening of drug combinations. To find combinations that exhibit an interaction effect, one filters for promising compound combinations by comparing to a response without interaction. A common principle for no interaction is Loewe Additivity which is based on the assumption that no compound interacts with itself and that two doses from different com...

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Additive Dose Response Models: Explicit Formulations and the Loewe Additivity Consistency Condition

High-throughput techniques allow for massive screening of drug combinations. To find combinations that exhibit an interaction effect, one filters for promising compound combinations by comparing to a response without interaction. A common principle for no interaction is Loewe Additivity which is based on the assumption that no compound interacts with itself and that doses of both compounds for ...

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‘Additive difference’ models without additivity and subtractivity

This paper studies conjoint measurement models tolerating intransitivities that closely resemble Tversky’s additive difference model while replacing additivity and subtractivity by mere decomposability requirements. We offer a complete axiomatic characterization of these models without having recourse to unnecessary structural assumptions on the set of objects. This shows the pure consequences ...

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Antimicrobial combinations: Bliss independence and Loewe additivity derived from mechanistic multi-hit models.

Antimicrobial peptides (AMPs) and antibiotics reduce the net growth rate of bacterial populations they target. It is relevant to understand if effects of multiple antimicrobials are synergistic or antagonistic, in particular for AMP responses, because naturally occurring responses involve multiple AMPs. There are several competing proposals describing how multiple types of antimicrobials add up...

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‘ Additive difference ’ models without additivity and subtractivity 1 D . Bouyssou

This paper studies conjoint measurement models tolerating intransitivities that closely resemble Tversky’s additive difference model while replacing additivity and subtractivity by mere decomposability requirements. We offer a complete axiomatic characterization of these models without having recourse to unnecessary structural assumptions on the set of objects. This shows the pure consequences ...

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Additive Dose Response Models: Explicit Formulation and the Loewe Additivity Consistency Condition

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